Rac (GTPase)

Rac is a subfamily of the Rho family of GTPases^[1], small (~21 kDa) signaling G proteins (more specifically a GTPases).

The subgroup include:

References

^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. PMID 16949823.

Hydrolases: acid anhydride hydrolases (EC 3.6)

3.6.1

Pyrophosphatase (Inorganic, Thiamine) · Apyrase · Thiamine-triphosphatase

3.6.2

Adenylylsulfatase · Phosphoadenylylsulfatase

3.6.3-4: ATPase

3.6.3

Cu++ (3.6.3.4)	Menkes/ATP7A · Wilson/ATP7B

Ca+ (3.6.3.8)	SERCA (ATP2A1, ATP2A2, ATP2A3) · Plasma membrane (ATP2B1, ATP2B2, ATP2B3, ATP2B4) · SPCA (ATP2C1, ATP2C2)

Na+/K+ (3.6.3.9)	ATP1A1 · ATP1A2 · ATP1A3 · ATP1A4 · ATP1B1 · ATP1B2 · ATP1B3 · ATP1B4

H+/K+ (3.6.3.10)	ATP4A

Other P-type ATPase	ATP8B1 · ATP10A · ATP11B · ATP12A · ATP13A2 · ATP13A3 ·

3.6.4

Dynein · Kinesin · Myosin

3.6.5: GTPase

3.6.5.1: Heterotrimeric G protein	G_αs · G_αi (GNAI1, GNAI2, GNAI3) · G_αq/11 (GNAQ, GNA11) · G_α12/13 (GNA12, GNA13) · Transducin (GNAT1, GNAT2)

3.6.5.2: Small GTPase > Ras superfamily	Rho family of GTPases: Cdc42 (CDC42, TC10, TCL) • RhoUV (RhoU, RhoV) • Rac (Rac1, 2, 3, RhoG) • RhoBTB (1, 2) • RhoH • Rho (A, B, C) • Rnd (1, 2, 3) • RhoDF (RhoF, RhoD) other: Ras (HRAS, KRAS, NRAS) · Rab (RAB23, RAB27) · Arf (ARF6, SAR1B, ARL13B, ARL6) · Ran · Rheb · Rap

3.6.5.3: Protein-synthesizing GTPase	Prokaryotic (IF-2, EF-Tu, EF-G) · Eukaryotic

3.6.5.5-6: Polymerization motors	Dynamin · Tubulin

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6